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Institute for Medical Research Management and Biometrics

Research

IMEREM is proud to contribute to publications or even write such publications about studies we are involved in. The following list presents publications with authors from IMEREM's employees. Topics of IMEREM's own research and scientific development:

Quality of life: In the areas of oncology, psychiatry, neurology, pediatry, dermatology and renal transplantation we are engaged in both development and evaluation of psychometric instruments for the measurement of quality of life. We have developed the socalled Welzel-Kohnen Coloured Scales for Quality of Life which allow to measure short-term changes in quality of life during pharmacological treatments; this scale is now translated in foreign languages to take advantage from its culture-free conceptualisation (rating by degrees of saturation of colours). A recent project developed the "Tübingen Quality of Life Questionnaire for Chronic Veneous Disease" together with the Dermatology Hospital at the University of Tübingen (PD M. Jünger, formerly also Dr. Klyscz). We have completed our research on our "How to you do?"-Scales for measurement of quality of life in children.

Scale development and validation: We developed and validated a scale for measuring symptoms of cold, the respective publication is in preparation. Additionally, we validate existing scales for German language (e.g., PRIME-MD) or evaluate scales which have been used in our trials retrospectively (scales for back pain assessment).

Studies in traffic safety: The influence of low dosages of alcohol as well as that of drugs on traffic safety was investigated and published (Bundesanstalt für Straßenwesen, Bergisch-Gladbach; cf. Medikamente im Straßenverkehr, Fischer 1995). We are available to perform phase-I studies in experimental designs including driving simulator in cooperation with a center of traffic research in Germany.

Biometrics: We are publishing on nonparametric statistical methods especially related to the Configural Frequency Analysis in cooperation with Prof. A. von Eye (Michigan State University) and Prof. G.A. Lienert, one of the mentors of nonparametric statistics in Germany (University of Erlangen-Nürnberg).

Development of automatic devices for measuring CNS-activity (measuring patterns of speech) and motoric behavior (actigraphy) and application in phase-I-studies with human volunteers as well as in patients (paper e.g., in Sleep).